Dexamethasone, a corticosteroid, is analogous to a natural hormone produced by adrenal glands. It is employed to exchange this chemical when your body doesn\'t make enough of it. It relieves inflammation (swelling, heat, redness, and pain) and is employed to treat certain sorts of arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders (e.g., colitis); severe allergies; and asthma. Dexamethasone is treating certain sorts of cancer. There are studies tells us that administration of dexamethasone to pregnant women increases the risk of birth defect in the offspring and possible also other adverse effect in the exposed infant. The present work studied the ameliorative effect of fennel oil against teratogenic effect induced by the dexamethasone in albino rats. The animals were divided into 4 groups: group 1 (control), group 2: the pregnant rat orally given fennel oil (one ml/kg body weight), group 3: the pregnant rat orally-administered with human equivalent dose 0.13 mg/Kg dexamethasone and group 4: the pregnant rat oral administered with dexamethasone followed by fennel oil from 5th day of gestation to 19th day of gestation. The pregnant rats were sacrificed under anesthesia at 20th day of gestation. The uteri horns were isolated, and the numbers of resorbed sites were determined. In addition, the morphological examination and skeletal staining of fetuses and the histological studies on fetal liver have been done. The Result showed decrease in both corrected body weight and placenta weight of pregnant mother and high incidence of resorption. Many hematomas in many parts of body and other malformations represented in deformed fore limb were recorded in group treated with dexamethasone. The skeletal malformation summarized as less degree of ossification, complete unossified bones, wavy ribs, curved ribs and costal separation in group treated with dexamethasone. The histopathological change summarized in pyknoses of some liver cells, necrotic area and fatty degeneration were noticed in histology of liver in group treated with dexamethasone. While the group treated with dexamethasone followed by fennel oil showed ameliorative effect in which the number of resorbed sites and hematoma were decreased, more bones were completely ossified and there are not any ribs anomalies were recorded. There was improvement in hepatic tissue as the architecture become more organized. Therefore, the fennel oil is given with dexamethasone to avoid embryotoxic effect induced by dexamethasone during pregnancy.